A study published in the journal Cell Metabolism by a group of Yale researchers found that the consumption of the common artificial sweetener sucralose (which is found in Splenda, Zerocal, Sukrana, SucraPlus and other brands) in combination with carbohydrates can swiftly turn a healthy person into one with high blood sugar. From whole grain English muffins to reduced-sugar ketchup, sucralose is found in thousands of baked goods, condiments, syrups and other consumer packaged goods – almost all of them containing carbs. The finding, which researchers noted has yet to be replicated in other studies, raises new questions about the use of artificial sweeteners and their effects on weight gain and overall health. In the Yale study, researchers took 60 healthy-weight individuals and separated them into three groups: A group that consumed a regular-size beverage containing the equivalent of two packets of sucralose sweetener, a second group that consumed a beverage sweetened with table sugar at the equivalent sweetness, and a third control group that had a beverage with the artificial sweetener as well as a carbohydrate called maltodextrin. The molecules of maltodextrin don’t bind to taste receptors in the mouth and are impossible to detect. While the sensation of the third group’s beverage was identical to the sucralose-only group, only this group exhibited significant adverse health effects. The artificial sweetener by itself seemed to be fine, the researchers discovered, but that changed when combined with a carbohydrate. Seven beverages over two weeks and the previously healthy people in this group became glucose intolerant, a metabolic condition that results in elevated blood glucose levels and puts people at an increased risk for diabetes. The finding follows a study in the journal JAMA Internal Medicine last year that found that consumption of two or more glasses of artificially sweetened soft drinks a day increased deaths from circulatory diseases. And a 2008 study by scientists at Purdue University showed that artificial sweeteners alone could result in higher blood pressure, weight gain, and increased risk of diabetes, stroke and heart disease in rats. The scientists in that Purdue study fed yogurt sweetened with glucose (a simple sugar with 15 calories/teaspoon, the same as table sugar) to a group of rats. A second group got yogurt sweetened with zero-calorie saccharin. This group consumed more calories, gained more weight, put on more body fat and didn’t make up for it by cutting back later. The researchers developed the “uncoupling hypothesis,” theorizing that disconnecting sweet taste from calories results in an impaired ability to use sweet taste to guide how much to eat and the perception of satiation. Dana Small, divisional director of nutritional psychiatry at Yale, and her colleagues in the Cell Metabolism study wondered something about the methods in Purdue’s experiment. It was that yogurt, high in carbs. “The uncoupling hypothesis made a lot of sense,” Small said by phone. “But we wanted to evaluate it in humans.” The researchers found that artificial sweetener on its own did not affect metabolism, “but when you have it with a carbohydrate it’s mishandled in such a way to have an adaptation in the brain and the sensitivity to sweetness is changed.” Insulin was significantly higher in the combination group. That means they needed to release more insulin to achieve the same blood glucose levels, an indication of decreased insulin sensitivity. That can lead to metabolic dysfunction and weight gain. Frank Hu, professor and chair of the department of nutrition at Harvard’s T.H. Chan School of Public Health, who has done extensive research on low-calorie sweeteners, says that while this is an interesting study, the findings are somewhat surprising and need to be replicated in future studies.
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